The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
이인송, 장준호, 김대원, 김성곤, 김태우,
소속 상세정보
이인송 ( Lee In-Song ) - Seoul National University School of Dentistry Department of Orthodontics
장준호 ( Chang Jun-Ho ) - Seoul National University School of Dentistry Department of Orthodontics
김대원 ( Kim Dae-Won ) - Gangneung-Wonju National University College of Dentistry Department of Oral Biochemistry
김성곤 ( Kim Seong-Gon ) - Gangneung-Wonju National University College of Dentistry Department of Oral and Maxillofacial Surgery
김태우 ( Kim Tae-Woo ) - Seoul National University School of Dentistry Department of Orthodontics
Abstract
Background: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.
Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1?100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
Results: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1?100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
키워드
4-hexylresorcinol; Sirtuin; NAD+
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